Determinants of blood eosinophil levels in the general population and patients with COPD: a population-based, epidemiological study

Respiratory Research

Julio Ancochea¹  Juan José Soler-Cataluña¹  Joan B. Soriano¹  Borja G. Cosío¹  Francisco García-Río¹  M. Guadalupe Sánchez-Herrero²  Marc Miravitlles³  Pilar de Lucas⁴  Ciro Casanova⁵  José Miguel Rodríguez González-Moro⁶  Inmaculada Alfageme⁷ 

[1] CIBER de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III (ISCIII);Departamento Médico, GSK, Tres Cantos;Pneumology Department, Hospital Universitari Vall d’Hebron/Vall d’Hebron Institut de Recerca (VHIR), Vall d’Hebron Barcelona Hospital Campus;Servicio de Neumología, Hospital General Gregorio Marañon;Servicio de Neumología, Hospital Universitario Nuestra Señora de Candelaria;Servicio de Neumología, Hospital Universitario “Príncipe de Asturias”, Alcalá de Henares, Universidad de Alcalá;Unidad de Gestión Clínica de Neumología, Hospital Universitario Virgen de Valme, Universidad de Sevilla;

关键词: Epidemiology;    Computed tomography;    Imaging population;    Biomarkers;   

DOI  :  10.1186/s12931-022-01965-3

来源: DOAJ

【 摘 要 】

Abstract Background Blood eosinophils are considered a biomarker for the treatment of chronic obstructive pulmonary disease (COPD). Population-based studies are needed to better understand the determinants of the blood eosinophil count (BEC) in individuals with and without COPD. Methods EPISCAN II is a multicentre, cross-sectional, population-based epidemiological study aimed at investigating the prevalence and determinants of COPD in Spain. Study subjects were randomly selected from the general population, and COPD was defined by a post-bronchodilator FEV1/FVC < 0.7. For the pre-specified outcomes related to BEC, the first 35 COPD and 35 non-COPD subjects were consecutively recruited in 12 of the participating centres with the objective of analysing 400 individuals in each group. Baseline BEC and its association with demographic, clinical and functional variables were analysed. Results A total of 326 COPD and 399 non-COPD subjects were included in the analysis. The mean age (standard deviation [SD]) was 63.2 years (11.0), 46.3% were male, and 27.6% were active smokers. BEC was significantly higher in individuals with COPD [192 cells/μL (SD: 125) vs. 160 cells/μL (SD: 114); p = 0.0003]. In a stepwise multivariate model, being male, active smoker and having a previous diagnosis of asthma were independently associated with having a higher BEC. Conclusions This population-based study estimated the distribution of eosinophils in the healthy adult population and concluded that COPD patients have a significantly higher BEC. Male sex, active smoking and concomitant asthma were significantly associated with a higher BEC.

【 授权许可】

Unknown