Multifunctional Bioactive Resin for Dental Restorative Materials

Polymers

Francesco Riccitiello¹  Ilenia De Luca²  Andrea Sorrentino³  Vittoria Vittoria⁴  Loredana Tammaro⁵  Anna Di Salle⁶  Anna Calarco⁶  Gianfranco Peluso⁶ 

[1] Department of Restorative Dentistry, University of Naples Federico II, via S. Pansini 5, 80131 Napoli, Italy;Elleva Pharma s.r.l., via P. Castellino 111, 80131 Napoli, Italy;Institute for Polymer, Composites and Biomaterials (IPCB)—CNR, P.le E. Fermi 1, 80055 Portici (Na), Italy;NICE FILLER s.r.l., via Loggia dei Pisani 25, 80133 Napoli, Italy;Nanomaterials and Devices Laboratory (SSPT-PROMAS-NANO), Italian National Agency for New Technologies, Energy and Sustainable Economic Development, ENEA, P.le E. Fermi 1, 80055 Portici (Na), Italy;Research Institute on Terrestrial Ecosystems (IRET)—CNR, via P. Castellino 111, 80131 Napoli, Italy;

关键词: dental materials;    composite resin;    layered double hydroxide;    calcium bentonite;    antibiofilm activity;   

DOI  :  10.3390/polym12020332

来源: DOAJ

【 摘 要 】

Resin-based composites are widely used as dental restorative materials due to their excellent properties. They must have high modulus, high hardness, and be chemically inert while minimizing moisture uptake. To fulfill these higher standard prerequisites and properties, continuous improvements in each of their components are required. This study develops novel composites with multiple biofunctions. Light-cured Bis-GMA/TEGDMA dental resin (RK)/layered double hydroxide intercalated with fluoride ions (LDH-F)/calcium bentonite (Bt) hybrid composites were prepared. The loading ratio of LDH-F to Bt was varied, ranging from 2.5/2.5 to 10/10 parts per hundred RK and structural, mechanical, and biological properties were studied. The incorporation of even small mass fractions (e.g., 2.5 wt% of LDH-F and 2.5 wt% of Bt) in RK dental resin significantly improved the mechanical properties of the pristine resin. The synthetized materials showed antibacterial and antibiofilm effects against three bacterial strains isolated from healthy volunteers’ saliva (Streptococcus spp., Bacteroides fragilis, and Staphylococcus epidermidis) without affecting its ability to induce dental pulp stem cells differentiation into odontoblast-like cells. The capability to balance between the antibiofilm activity and dental pulp stem cells differentiation in addition with improved mechanical properties make these materials a promising strategy in preventive and restorative dentistry.

【 授权许可】

Unknown