期刊论文详细信息
Frontiers in Genetics
Phthalate Exposure and Long-Term Epigenomic Consequences: A Review
Diana K. Haggerty1  Sudipta Dutta3  Douglas M. Ruden4  Daniel A. Rappolee5 
[1] Department of Epidemiology and Biostatistics, Michigan State University, East Lansing, MI, United States;Department of Obstetrics and Gynecology, Reproductive Endocrinology and Infertility, CS Mott Center for Human Growth and Development, Wayne State University School of Medicine, Detroit, MI, United States;Department of Obstetrics and Gynecology, University of Nebraska Medical Center, Omaha, NE, United States;Institutes for Environmental Health Science, Wayne State University School of Medicine, Detroit, MI, United States;Reproductive Stress, Inc., Grosse Pointe Farms, MI, United States;
关键词: phthalates;    epigenomics;    DNA methylation;    DOHAD;    gestational exposure;   
DOI  :  10.3389/fgene.2020.00405
来源: DOAJ
【 摘 要 】

Phthalates are esters of phthalic acid which are used in cosmetics and other daily personal care products. They are also used in polyvinyl chloride (PVC) plastics to increase durability and plasticity. Phthalates are not present in plastics by covalent bonds and thus can easily leach into the environment and enter the human body by dermal absorption, ingestion, or inhalation. Several in vitro and in vivo studies suggest that phthalates can act as endocrine disruptors and cause moderate reproductive and developmental toxicities. Furthermore, phthalates can pass through the placental barrier and affect the developing fetus. Thus, phthalates have ubiquitous presence in food and environment with potential adverse health effects in humans. This review focusses on studies conducted in the field of toxicogenomics of phthalates and discusses possible transgenerational and multigenerational effects caused by phthalate exposure during any point of the life-cycle.

【 授权许可】

Unknown   

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