Marine Bioactive Compounds against Aspergillus fumigatus: Challenges and Future Prospects

Antibiotics

BlessingC. Ezeuduji¹  AnthonyC. Ike²  AneneN. Moneke²  JamesC. Ogbonna²  Bin Wang³  ChukwuemekaSamson Ahamefule³  Wenxia Fang³  Cheng Jin³ 

[1] Department of Microbiology, University of Jos, Jos 930001, Nigeria;Department of Microbiology, University of Nigeria, Nsukka 410001, Enugu State, Nigeria;National Engineering Research Center for Non-food Biorefinery, Guangxi Academy of Sciences, Nanning 530007, Guangxi, China;

关键词: marine resources;    Aspergillus fumigatus;    bioactive compounds;    screening model;    fungi;   

DOI  :  10.3390/antibiotics9110813

来源: DOAJ

【 摘 要 】

With the mortality rate of invasive aspergillosis caused by Aspergillus fumigatus reaching almost 100% among some groups of patients, and with the rapidly increasing resistance of A. fumigatus to available antifungal drugs, new antifungal agents have never been more desirable than now. Numerous bioactive compounds were isolated and characterized from marine resources. However, only a few exhibited a potent activity against A. fumigatus when compared to the multitude that did against some other pathogens. Here, we review the marine bioactive compounds that display a bioactivity against A. fumigatus. The challenges hampering the discovery of antifungal agents from this rich habitat are also critically analyzed. Further, we propose strategies that could speed up an efficient discovery and broaden the dimensions of screening in order to obtain promising in vivo antifungal agents with new modes of action.

【 授权许可】

Unknown