Perinatal Hypoxia and Ischemia in Animal Models of Schizophrenia

Frontiers in Psychiatry

Dragos Inta¹  Peter Gass²  Dimitri Hefter³  Hugo H. Marti⁴ 

[1] Department of Psychiatry, University of Basel, Basel, Switzerland;RG Animal Models in Psychiatry, Department of Psychiatry and Psychotherapy, Medical Faculty Mannheim, Central Institute of Mental Health, University of Heidelberg, Heidelberg, Germany;RG Neuro- and Sensory Physiology, Institute of Physiology and Pathophysiology, University of Heidelberg, Heidelberg, Germany;RG Neurovascular Research, Institute of Physiology and Pathophysiology, University of Heidelberg, Heidelberg, Germany;

关键词: perinatal;    hypoxia;    schizophrenia;    ischemia;    animal models;    neurodevelopment;   

DOI  :  10.3389/fpsyt.2018.00106

来源: DOAJ

【 摘 要 】

Intrauterine or perinatal complications constitute a major risk for psychiatric diseases. Infants who suffered from hypoxia–ischemia (HI) are at twofold risk to develop schizophrenia in later life. Several animal models attempt to reproduce these complications to study the yet unknown steps between an insult in early life and outbreak of the disease decades later. However, it is very challenging to find the right type and severity of insult leading to a disease-like phenotype in the animal, but not causing necrosis and focal neurological deficits. By contrast, too mild, repetitive insults may even be protective via conditioning effects. Thus, it is not surprising that animal models of hypoxia lead to mixed results. To achieve clinically translatable findings, better protocols are urgently needed. Therefore, we compare widely used models of hypoxia and HI and propose future directions for the field.

【 授权许可】

Unknown