A Comprehensive Analysis of Plasma Cytokines and Metabolites Shows an Association between Galectin-9 and Changes in Peripheral Lymphocyte Subset Percentages Following Coix Seed Consumption

Nutrients

Minami Jinnouchi¹  Yoshio Suzuki¹  Taisei Miyahara¹  Naoko Kaga²  Yoshiki Miura²  Hikari Taka²  Akiko Ohara-Takada³ 

[1] Graduate School of Health and Sports Science, Juntendo University, Inzai 270-1695, Japan;Laboratory of Proteomics and Biomolecular Science, Biomedical Research Core Facilities, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan;Research Center of Genetic Resources, National Agriculture and Food Research Organization, Tsukuba 305-8602, Japan;

关键词: metabolome;    adlay;    pearl barley;    gut microbiota;    omics;   

DOI  :  10.3390/nu14091696

来源: DOAJ

【 摘 要 】

We previously reported that healthy adult males who consumed coix seeds for 1 week demonstrated an increased intestinal abundance of Faecalibacterium prausnitzii and altered peripheral lymphocyte subset percentages. However, the mechanism underlining these effects has not been elucidated. Therefore, cytokines and metabolites in plasma obtained in this study are comprehensively analyzed. A total of 56 cytokines and 52 metabolites in the plasma are quantified. Among them, 14 cytokines and 9 metabolites show significant changes in their levels following coix seed consumption. We examine the relationship between these changes and those in peripheral lymphocyte subset percentages and intestinal abundance of F. prausnitzii, which is also considerably altered following coix seed consumption. The galectin-9 concentration considerably decreased after coix seed consumption, and these changes correlate with those in cytotoxic T cells and pan T cells. Therefore, galectin-9 is possibly involved in the changes in peripheral lymphocyte subset percentages induced by coix seed consumption.

【 授权许可】

Unknown