Resilience integrates concepts in aging research

iScience

Marten Scheffer¹  Maria A. Riolo¹  Kelley Harris¹  Rozalyn M. Anderson²  James DeGregori³  Morgan E. Levine⁴  Barbara Natterson Horowitz⁵  Sabrina L. Spencer⁶  David S. Schneider⁷  Dario Riccardo Valenzano⁸  Michael E. Hochberg⁹  Daniel Promislow^1,10  Bernard Crespi^1,11 

[1] Corresponding author;Department of Biology, University of Washington, Seattle, WA 98195, USA;GRECC, William S. Middleton Memorial Veterans Hospital, Madison, WI 53705, USA;Santa Fe Institute, Santa Fe, NM 87501, USA;Department of Aquatic Ecology and Water Quality Management, Wageningen University, Wageningen, the Netherlands;Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA;Department of Biological Sciences, Simon Fraser University, Burnaby, BC V5A 1S6, Canada;Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA;Department of Human Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA;Department of Lab Medicine and Pathology, University of Washington School of Medicine, Seattle, WA 98195, USA;Department of Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53726, USA;

关键词: Health sciences;    Biological sciences;    Molecular biology;    Evolutionary biology;    Cell biology;   

DOI  :  

来源: DOAJ

【 摘 要 】

Summary: Aging research is unparalleled in the breadth of disciplines it encompasses, from evolutionary studies examining the forces that shape aging to molecular studies uncovering the underlying mechanisms of age-related functional decline. Despite a common focus to advance our understanding of aging, these disciplines have proceeded along distinct paths with little cross-talk. We propose that the concept of resilience can bridge this gap. Resilience describes the ability of a system to respond to perturbations by returning to its original state. Although resilience has been applied in a few individual disciplines in aging research such as frailty and cognitive decline, it has not been explored as a unifying conceptual framework that is able to connect distinct research fields. We argue that because a resilience-based framework can cross broad physiological levels and time scales it can provide the missing links that connect these diverse disciplines. The resulting framework will facilitate predictive modeling and validation and influence targets and directions in research on the biology of aging.

【 授权许可】

Unknown