Acinetobacter baumannii multirresistentes: emergênciade resistência à polimixina no Rio de Janeiro | Multidrug Resistant Acinetobacer baumanni: the occurrence ofpolymyxin resistance in Rio de Janeiro

Vigilância Sanitária em Debate: Sociedade, Ciência & Tecnologia

Eduardo de Almeida Ribeiro de Castro¹  Valéria Câmara Almeida¹  Maria Helena Simões Villas Bôas²  Gabrielle Limeira Genteluci³  Daniela Betzler Cardoso Gomes³  Karyne Rangel Carvalho³  Luciane Martins Medeiros⁴ 

[1] Hospital Municipal da Piedade, Riode Janeiro, RJ, Brasil;Instituto Nacional de Controle deQualidade em Saúde, FundaçãoOswaldo Cruz (INCQS/Fiocruz), Riode Janeiro, RJ, Brasil

[2]  E-mail: [e-mail];Instituto Nacional de Controle deQualidade em Saúde, FundaçãoOswaldo Cruz (INCQS/Fiocruz), Riode Janeiro, RJ, Brasil;Instituto de Tecnologia emImunobiológicos, Fundação OswaldoCruz (Bio-Manguinhos/Fiocruz), Riode Janeiro, RJ, Brasil;

关键词: such as polymyxins;    “last-resort” drugs for the clinical therapy.This study aimed to determine the susceptibility profile of 60 A. baumannii isolates froma hospital in the city of Rio de Janeiro;    27 isolates obtained from patients in an outbreakin 2011;    and a total of 33 isolates from both patients and the hospital environmentcollected in the 2014-15 period;    in the same hospital. Isolates showed high levels(≥ 80%) of resistance to the antimicrobials tested: piperacillin/tazobactam;    cefotaxime;    ciprofloxacin;    cefepime;    imipenem and meropenem. The highest resistance percentagepresented in isolates from the 2011 period was to ciprofloxacin (96%). Regarding theenvironmental isolates;    the highest resistance percentage was found to cefotaxime (94%).Among the 60 isolates tested;    19 (32%) were sensible to polymyxin B (MIC ≤ 2 mg/mL)and 41 (68%) were resistant (MIC ≥ 4 mg/mL);    27 were obtained from patients (20 fromthe 2011 period and 7 from the 2014-2015 period) and 14 from the hospital environment.The resistance to polymyxins is still rare;    however;    the extensive use of polymyxins hasled to the emergence of resistant strains of A. baumannii.;    Acinetobacter baumannii;    Resistência;    Polimixina B;    InfecçãoHospitalar;    Vigilância Sanitária;    Acinetobacter baumannii;    Resistance;    Polymyxin B;    Hospital Infections;    Sanitary Surveillance;   

DOI  :  10.22239/2317-269X.00732

来源: DOAJ

【 授权许可】

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