Human neuronal cells: epigenetic aspects

Biomolecular Concepts

Wyllie Tessa¹  Kukucka Jessica¹  Mahoney Lauren¹  Suphioglu Cenk¹  Read Justin¹ 

[1] NeuroAllergy Research Laboratory, Faculty of Science and Technology, School of Life and Environment Sciences, Deakin University, Geelong, Waurn Ponds, 3216 Victoria, Australia;

关键词: acetylation;    alzheimer’s disease;    deacetylation;    gene expression;    neuroprotection;    neurotoxicity;   

DOI  :  10.1515/bmc-2012-0053

来源: DOAJ

【 摘 要 】

Histone acetyltransferases (HATs) and histone deacetylases (HDACs) promote histone posttranslational modifications, which lead to an epigenetic alteration in gene expression. Aberrant regulation of HATs and HDACs in neuronal cells results in pathological consequences such as neurodegeneration. Alzheimer’s disease is the most common neurodegenerative disease of the brain, which has devastating effects on patients and loved ones. The use of pan-HDAC inhibitors has shown great therapeutic promise in ameliorating neurodegenerative ailments. Recent evidence has emerged suggesting that certain deacetylases mediate neurotoxicity, whereas others provide neuroprotection. Therefore, the inhibition of certain isoforms to alleviate neurodegenerative manifestations has now become the focus of studies. In this review, we aimed to discuss and summarize some of the most recent and promising findings of HAT and HDAC functions in neurodegenerative diseases.

【 授权许可】

Unknown