Effect of daily gavage with a collagen hydrolysate containing calcitonin gene-related peptide (CGRP)-like molecules on plasma CGRP-levels in rats

Journal of Functional Foods

Rozenn Ravallec¹  Benoit Cudennec²  Martine Fouchereau-Peron³  Oscar Martínez-Alvarez⁴  Laurence Guimas⁵  Charles Delannoy⁵ 

[1] Corresponding author. Tel.: [phone];fax: [phone].;COPALIS, BP 239, 62203 Boulogne-sur-Mer Cedex, France;Institute of Food Science, Technology and Nutrition (ICTAN-CSIC)2, José Antonio Novais 10, 28040 Madrid, Spain;ProBioGEM – Polytech’Lille – IUTA – EA 1026, 59655 Villeneuve d’Ascq Cedex, France;

关键词: CGRP;    Collagen;    By-products;    Simulated digestion;    Protein hydrolysates;    Wistar rats;   

DOI  :  

来源: DOAJ

【 摘 要 】

Siki (Centroscymnus coelolepis) hydrolysates may contain calcitonin gene-related peptide (CGRP)-like molecules. These CGRP-like molecules have attracted attention from the food industry due to their promising applications in the field of functional foods. These CGRP-like molecules were purified and sequenced, and found to show homology to fragments of fish and human collagen. The effect on plasma CGRP-levels of daily gavage with siki hydrolysate containing CGRP-like molecules was further studied in male Wistar rats. The plasma CGRP-levels in rats force fed with the siki hydrolysate were significantly higher than those of the control group. The siki hydrolysate included immunoreactive-CGRP molecules which resisted simulated protein digestion. They were able to cross the intestinal barrier intact and could be responsible for the increase in plasma CGRP levels. This increment in plasma CGRP levels was insufficient to affect body weight or food intake. However, it could lead to other beneficial effects on health.

【 授权许可】

Unknown