Effects of anodal transcranial direct current stimulation on motor evoked potentials variability in humans

Physiological Reports

Ali Hamza¹  Moath Alatefi²  Mohamed Sharaf²  Shafiq Ahmad²  Woo Kyoung Yoo³  Shirely Fecteau⁴  Shahid Bashir⁵ 

[1] Department of Electrical Engineering National University of Computer and Emerging Sciences Lahore Pakistan;Department of Industrial Engineering College of Engineering King Saud University Riyadh Saudi Arabia;Department of Physical Medicine and Rehabilitation Hallym University Sacred Heart Hospital Anyang South Korea;Medical School Laval University Quebec Canada;Neuroscience Center King Fahad Specialist Hospital Dammam Dammam Saudi Arabia;

关键词: Corticospinal excitability;    Motor cortex;    Motor evoked potentials;    Resting motor threshold;    Transcranial direct current stimulation;   

DOI  :  10.14814/phy2.14087

来源: DOAJ

【 摘 要 】

Abstract Motor evoked potentials (MEPs) obtained from transcranial magnetic stimulation (TMS) allow corticospinal excitability (CSE) to be measured in the human primary motor cortex (M1). CSE responses to transcranial direct current stimulation (tDCS) protocols are highly variable. Here, we tested the reproducibility and reliability of individual MEPs following a common anodal tDCS protocol. In this study, 32 healthy subjects received anodal tDCS stimulation over the left M1 for three durations (tDCS‐T5, tDCS‐T10, and tDCS‐T20 min) on separate days in a crossover‐randomized order. After the resting motor threshold (RMT) was determined for the contralateral first dorsal interosseous muscle, 15 single pulses 4–8 sec apart at an intensity of 120% RMT were delivered to the left M1 to determine the baseline MEP amplitude at T0, T5, T10, T20, T30, T40, T50, and T60 min after stimulation for each durations. During TMS delivery, 3D images of the participant's cortex and hot spot were visualized for obtaining MEPs from same position. Our findings revealed that there was a significant MEPs improvement at T0 (P = 0.01) after 10 min of anodal stimulation. After the 20‐min stimulation duration, MEPs differed specifically at T0, T5, T30 min (P < 0.05). This indicates that tDCS is a promising tool to improve MEPs. Our observed variability in response to the tDCS protocol is consistent with other noninvasive brain stimulation studies.

【 授权许可】

Unknown