Inflammatory Markers in Patients Using Domiciliary Non-invasive Mechanical Ventilation: C Reactive Protein, Procalcitonin, Neutrophil Lymphocyte Ratio

Frontiers in Public Health

Sinem Gungor¹  Huriye Berk Takir¹  Ilim Irmak¹  Eylem Tuncay¹  Ozlem Yazicioglu Mocin¹  Zuhal Karakurt¹  Emine Aksoy¹  Birsen Ocakli¹  Nezihe Ciftaslan Goksenoglu¹  Nalan Adiguzel¹  Meltem Sertbas² 

[1] Health Sciences University Süreyyapaşa Chest Diseases and Thoracic Surgery Training and Research Hospital, Maltepe, Turkey;Internal Medicine, Fatih Sultan Mehmet Education and Research Hospital, Ataşehir, Turkey;

关键词: domiciliary non-invasive mechanical ventilation;    inflammatory markers;    CRP;    procalcitonin;    neutrophil lymphocyte ratio;   

DOI  :  10.3389/fpubh.2018.00245

来源: DOAJ

【 摘 要 】

Aim: Early identification and treatment of infections in patients using domiciliary non-invasive mechanical ventilation (NIMV) due to chronic respiratory failure (CRF) can reduce hospital admissions. We assessed C-reactive protein (CRP), procalcitonin, and neutrophil lymphocyte ratio (NLR) as indicators of infection/inflammation.Methods: The study was designed as a retrospective, observational, cross-sectional study, and was performed in 2016 in an intensive care unit outpatient clinic in patients using NIMV. Patients who came to the outpatient clinic with dyspnea, increased sputum, increased prothrombin, and who had hemogram, procalcitonin, and serum CRP, NLR, and PLT/MPV levels assessed, were enrolled into the study. Demographic characteristics, co-morbid diseases, respiratory symptoms, hemogram, biochemistry, CRP, and procalcitonin values in stable and acute attack patients were recorded from patient files. The descriptive statistics and CRP, NLR, and procalcitonin values were assessed.Results: During the study period, 49 patients (24 female) with chronic obstructive pulmonary disease (COPD, n = 24), obesity hypoventilation syndrome (OHS, n = 15), or interstitial lung disease, n = 10), and having had three inflammatory markers assessed, were included in the study. Their mean age was 67 (SD ± 12). Stable patients vs. those who had an acute attack was 41 vs. eight, and within 7 days of outpatient admission four patients were hospitalized. CRP, NLR, and PLT/MPV values were similar in patients' who had sputum purulence, and an increase in dyspnea and sputum, but procalcitonin was significantly higher in patients who had an acute attack. Procalcitonin was not correlated with CRP, NLR, and PLT/MPV.Conclusions: Patients with CRF had similar levels of CRP and NLR during a stable and acute attack state. Procalcitonin may be a better marker for therapeutic decisions in advanced chronic inflammatory diseases.

【 授权许可】

Unknown