The Effects of Hypocapnia on Brain Tissue Pulsations

Brain Sciences

JatinderS. Minhas¹  Meshal Alharbi¹  Alanoud Almudayni¹  EmmaM.L. Chung¹  Poppy Turner¹  Jonathan Ince¹  Mitsuhiro Oura²  Andrea Lecchini-Visintini³  KelechiU. Ebirim³ 

[1] Cerebral Haemodynamics in Ageing and Stroke Medicine (CHiASM) Research Group, Department of Cardiovascular Sciences, University of Leicester, Leicester LE2 7LX, UK;Nihon Kohden Corporation, Tokorozawa-shi, Saitama 359-0037, Japan;School of Engineering, University of Leicester, Leicester LE1 7RH, UK;

关键词: hypocapnia;    brain tissue pulsations;    BTP;    cerebral autoregulation;   

DOI  :  10.3390/brainsci10090614

来源: DOAJ

【 摘 要 】

Hypocapnia is known to affect patients with acute stroke and plays a key role in governing cerebral autoregulation. However, the impact of hypocapnia on brain tissue pulsations (BTPs) is relatively unexplored. As BTPs are hypothesised to result from cerebrovascular resistance to the inflow of pulsatile arterial blood, it has also been hypothesised that cerebral autoregulation changes mediated by hypocapnia will alter BTP amplitude. This healthy volunteer study reports measurements of BTPs obtained using transcranial tissue Doppler (TCTD). Thirty participants underwent hyperventilation to induce mild hypocapnia. BTP amplitude, EtCO₂, blood pressure, and heart rate were then analysed to explore the impact of hypocapnia on BTP amplitude. Significant changes in BTP amplitude were noted during recovery from hypocapnia, but not during the hyperventilation manoeuvre itself. However, a significant increase in heart rate and pulse pressure and decrease in mean arterial pressure were also observed to accompany hypocapnia, which may have confounded our findings. Whilst further investigation is required, the results of this study provide a starting point for better understanding of the effects of carbon dioxide levels on BTPs. Further research in this area is needed to identify the major physiological drivers of BTPs and quantify their interactions with other aspects of cerebral haemodynamics.

【 授权许可】

Unknown