A Data Self-Calibration Method Based on High-Density Parallel Plate Diffuse Optical Tomography for Breast Cancer Imaging

Frontiers in Oncology

Yirong Wang¹  Fei Kang¹  Shouping Zhu²  Xin Wang²  Rui Hu²  Qiang Yan²  Yihan Wang² 

[1] Department of Nuclear Medicine, Xijing Hospital, Fourth Military Medical University, Xi’an, China;Engineering Research Center of Molecular and Neuro Imaging of Ministry of Education, Xi’an, China;School of Life Science and Technology, Xidian University, Xi’an, China;

关键词: diffuse optical tomography (DOT);    data calibration;    medical optics instrumentation;    image reconstruction;    breast cancer;   

DOI  :  10.3389/fonc.2021.786289

来源: DOAJ

【 摘 要 】

When performing the diffuse optical tomography (DOT) of the breast, the mismatch between the forward model and the experimental conditions will significantly hinder the reconstruction accuracy. Therefore, the reference measurement is commonly used to calibrate the measured data before the reconstruction. However, it is complicated to customize corresponding reference phantoms based on the breast shape and background optical parameters of different subjects in clinical trials. Furthermore, although high-density (HD) DOT configuration has been proven to improve imaging quality, a large number of source-detector (SD) pairs also increase the difficulty of multi-channel correction. To enhance the applicability of the breast DOT, a data self-calibration method based on an HD parallel-plate DOT system is proposed in this paper to replace the conventional relative measurement on a reference phantom. The reference predicted data can be constructed directly from the measurement data with the support of the HD-DOT system, which has nearly a hundred sets of measurements at each SD distance. The proposed scheme has been validated by Monte Carlo (MC) simulation, breast-size phantom experiments, and clinical trials, exhibiting the feasibility in ensuring the quality of the DOT reconstruction while effectively reducing the complexity associated with relative measurements on reference phantoms.

【 授权许可】

Unknown