Surgical Applications of Materials Engineered with Antimicrobial Properties

Bioengineering

Jessica F. Kim¹  Geoffrey C. Gurtner²  Ayushi Sharma³  Derrick C. Wan⁴  David P. Perrault⁴ 

[1] Department of Medicine, Loma Linda University School of Medicine, Loma Linda, CA 92350, USA;Department of Surgery, University of Arizona School of Medicine, Tucson, AZ 85724, USA;Division of Plastic and Reconstructive Medicine, Stanford University School of Medicine, Stanford University, Stanford, CA 94305, USA;Hagey Laboratory for Pediatric Regenerative Medicine, Stanford University School of Medicine, Stanford University, Stanford, CA 94305, USA;

关键词: implant infection;    surgical site infection;    implant coating;    antifouling;    antibacterial coating;    nanostructured surface;   

DOI  :  10.3390/bioengineering9040138

来源: DOAJ

【 摘 要 】

The infection of surgically placed implants is a problem that is both large in magnitude and that broadly affects nearly all surgical specialties. Implant-associated infections deleteriously affect patient quality-of-life and can lead to greater morbidity, mortality, and cost to the health care system. The impact of this problem has prompted extensive pre-clinical and clinical investigation into decreasing implant infection rates. More recently, antimicrobial approaches that modify or treat the implant directly have been of great interest. These approaches include antibacterial implant coatings (antifouling materials, antibiotics, metal ions, and antimicrobial peptides), antibacterial nanostructured implant surfaces, and antibiotic-releasing implants. This review provides a compendium of these approaches and the clinical applications and outcomes. In general, implant-specific modalities for reducing infections have been effective; however, most applications remain in the preclinical or early clinical stages.

【 授权许可】

Unknown