MiRNAs as Players in Rhabdomyosarcoma Development

International Journal of Molecular Sciences

Andrea Ferrari¹  Francesca Limido¹  Gabriella Sozzi¹  Orazio Fortunato²  Maura Massimino²  Michela Casanova²  Patrizia Gasparini³ 

[1] Fondazione IRCCS Istituto Nazionale dei Tumori, Via Venezian 1, 20133 Milan, Italy;Pediatric Oncology Unit;Tumor Genomics Unit, Department of Research;

关键词: rhabdomyosarcoma;    microrna;    pediatric tumors;   

DOI  :  10.3390/ijms20225818

来源: DOAJ

【 摘 要 】

Rhabdomyosarcoma (RMS), the most common soft tissue sarcoma of childhood and adolescence, is a rare but aggressive malignancy that originates from immature mesenchymal cells committed to skeletal muscle differentiation. Although RMS is, generally, responsive to the modern multimodal therapeutic approaches, the prognosis of RMS depends on multiple variables and for some patients the outcome remains dismal. Further comprehension of the molecular and cellular biology of RMS would lead to identification of novel therapeutic targets. MicroRNAs (miRNAs) are small non-coding RNAs proved to function as key regulators of skeletal muscle cell fate determination and to play important roles in RMS pathogenesis. The purpose of this review is to better delineate the role of miRNAs as a biomarkers or functional leaders in RMS development, so to possibly elucidate some of RMS molecular mechanisms and potentially therapeutically target them to improve clinical management of pediatric RMS.

【 授权许可】

Unknown