Critical Review of Volatile Organic Compound Analysis in Breath and In Vitro Cell Culture for Detection of Lung Cancer

Metabolites

Thirumalai Venkatesan¹  ViknishKrishnan Kutty¹  Zhunan Jia¹  Abhijeet Patra¹ 

[1] NUSNNI-Nanocore, National University of Singapore, Singapore 117411, Singapore;

关键词: volatile organic compound;    lung cancer;    breath analysis;    in vitro study;    biomarker;   

DOI  :  10.3390/metabo9030052

来源: DOAJ

【 摘 要 】

Breath analysis is a promising technique for lung cancer screening. Despite the rapid development of breathomics in the last four decades, no consistent, robust, and validated volatile organic compound (VOC) signature for lung cancer has been identified. This review summarizes the identified VOC biomarkers from both exhaled breath analysis and in vitro cultured lung cell lines. Both clinical and in vitro studies have produced inconsistent, and even contradictory, results. Methodological issues that lead to these inconsistencies are reviewed and discussed in detail. Recommendations on addressing specific issues for more accurate biomarker studies have also been made.

【 授权许可】

Unknown