The role of lipid dysregulation and vascular risk factors in glaucomatous retrobulbar circulation

Bosnian Journal of Basic Medical Sciences

Anna Modrzejewska¹  Monika Modrzejewska²  Daniel Zaborski³  Wilhelm Grzesiak³ 

[1] Department of Ophthalmology, Pomeranian Medical University Hospital, Szczecin,;Department of Ophthalmology, Pomeranian Medical University, Szczecin;Laboratory of Biostatistics, West Pomeranian University of Technology, Szczecin;

关键词: primary open angle glaucoma;    retrobulbar circulation;    color Doppler imaging;    vascular and lipid-related risk factors;    ocular hemodynamics;   

DOI  :  10.17305/bjbms.2015.299

来源: DOAJ

【 摘 要 】

The aim of this study was to evaluate selected lipid-related and vascular factors and their effect on retrobulbar hemodynamics in glaucoma. Fifty-six patients with primary open angle glaucoma (POAG) [POAG group; mean age 68.32 years (SD±0.21)] and 54 patients in control group [CG, mean age 68.1 years (SD±5.34)] were examined. Peak systolic velocity, end-diastolic velocity, mean velocity, pulsatility index, and resistive index of the ophthalmic artery, the central retinal artery and the posterior ciliary arteries were measured by Color Doppler Imaging. Selected lipid-related, systemic and local vascular parameters were evaluated. Statistical methods included Shapiro-Wilk, Student-t and Mann-Whitney U tests, and Spearman rank correlations. In POAG group systolic arterial blood pressure, diastolic arterial blood pressure, total cholesterol, low density lipoprotein cholesterol (LDL-ch), and intraocular pressure were significantly higher; while ocular perfusion pressure, high density lipoprotein cholesterol (HDL-ch) and diastolic ocular perfusion pressure were significantly lower (p≤0.05). Color Doppler Imaging confirmed blood flow abnormalities in all investigated arteries. In addition, significant correlations of HDL-ch, LDL-ch and triglycerides (TG) with peak systolic velocity, end-diastolic velocity and mean velocity were found in individual arteries (p≤0.05). Also, significant associations of systolic arterial blood pressure, ocular perfusion pressure, systolic oclular perfusion pressure and diastolic ocular perfusion pressure with peak systolic velocity, end-diastolic velocity, mean velocity and resistive index were revealed in the posterior ciliary arteries (p≤0.05). Dysregulation of lipid-related and vascular factors, as well as statistical correlation between the above and retrobulbar blood flow indices, might imply their role in vasoconstrictive processes during glaucomatous endotheliopathy.

【 授权许可】

Unknown