Immunological properties of the bacterial origin compounds

Harčova Nauka ì Tehnologìâ

关键词: immunotropic properties;    bacterias;    teichoic acids;    peptidoglycan;    muramildipeptyd;    destruction;    enzymes;   

DOI  :  10.15673/fst.v10i3.175

来源: DOAJ

【 摘 要 】

It is shown that microorganisms are an integral element of the mаcroorganism immune system.
Peptidoglycan, muramyldypeptyd, teichoic acids are structural components of cell walls of microorganisms. These components
are an object for recognition of the innate immunity system. The necessity of the bacteria cell walls destruction with a view to
obtain the immunotropic products for enteral consumption, able to overcome the intestinal barrier, was substantiated.
The use of lactic acid bacteria (ICD) for such purposes is perspective and safe, since the considerable experience of
their cultivation was accumulated, in addition, ICD have got «GRAS» (Generally Recognized As Safe) status. Waste products
of ICD are organic acids, hydrogen peroxide, bacteriocins and others. These substances have got antagonist activity, implicitly
affect on the immune system, reducing the antigenic load caused by pathogenic microorganisms.
A number of physical, chemical and biochemical methods of bacteria cell walls destruction were considered. The
priority methods is the soft influence, namely the use of specific enzymes or hydrolases, own autolyzins with a combination of
physical destruction methods.

【 授权许可】

Unknown