High prevalence of low HDL cholesterol concentrations and mixed hyperlipidemia in a Mexican nationwide survey

Journal of Lipid Research

Gustavo Olaiz¹  Francisco J. Gómez Pérez²  Juan Manuel Ríos Torres²  Juan A. Rull²  Rosalba Rojas²  Victoria Valles³  Jaime Sepulveda³  Aurora Franco³  Carlos A. Aguilar-Salinas⁴ 

[1] Departamento de Endocrinología y Metabolismo de Lípidos, del Instituto Nacional de Ciencias Médicas y Nutrición, Vasco de Quiroga 15, Mexico City 14000, Mexico;Departamento de Endocrinología y Metabolismo de Lípidos, del Instituto Nacional de Ciencias Médicas y Nutrición, Vasco de Quiroga 15, Mexico City 14000, Mexico;Instituto Nacional de Salud Publica, Cuernavaca, Morelos, Mexico;To whom correspondence should be addressed.;

关键词: diabetes;    obesity;    hypertension;    cholesterol;    Mexico;    insulin resistance;   

DOI  :  

来源: DOAJ

【 摘 要 】

The prevalence of lipid abnormalities revealed in a survey done in 417 Mexican cities is described. Information was obtained on 15,607 subjects, aged 20 to 69 years. In this report, only samples obtained after a 9- to 12-h fast were included (2,256 cases: 953 men and 1,303 women). The population is representative of Mexican urban adults. Mean lipid concentrations were: cholesterol, 4.80 mmol/l; triglycerides, 2.39 mmol/l; HDL cholesterol, 1.00 mmol/l; and LDL cholesterol, 3.06 mmol/l. The most prevalent abnormality was HDL cholesterol below 0.9 mmol/l (46.2% for men and 28.7% for women). Hypertriglyceridemia (>2.26 mmol/l) was the second most prevalent abnormality (24.3%). Severe hypertriglyceridemia (>11.2 mmol/l) was observed in 0.42% of the population. Increased LDL cholesterol (≥4.21 mmol/l) was observed in 11.2% of the sample. Half of the hypertriglyceridemic subjects had a mixed dyslipidemia or low HDL cholesterol. More than 50% of the low HDL cholesterol cases were not related to hypertriglyceridemia. Insulin resistance was found in 59% of them. In conclusion, the prevalence of hypoalphalipoproteinemia and other forms of dyslipidemia in Mexican adults is very high and it is among the highest previously reported worldwide. —Aguilar-Salinas, C. A., G. Olaiz, V. Valles, J. M. Ríos Torres, F. J. Gómez Pérez, J. A. Rull, R. Rojas, A. Franco, and J. Sepulveda. High prevalence of low HDL cholesterol concentrations and mixed hyperlipidemia in a Mexican nationwide survey.

【 授权许可】

Unknown