The repurposing of Tebipenem pivoxil as alternative therapy for severe gastrointestinal infections caused by extensively drug-resistant Shigella spp

eLife

Patricia Pavlinac¹  Denise Dayao²  Tzipori Saul²  Judd Walson³  Molly McCloskey³  Shareef Shaheen³  Samuel LM Arnold³  Jaime de Mercado⁴  Elena Fernández Álvaro⁴  Cristina de Cozar⁴  Adolfo García-Perez⁴  Pablo Castañeda⁴  Beatriz Urones⁴  Lluis Ballell Pages⁴  Alvaro Cortés⁴  Alan Price⁴  Maria Santos Martínez-Martínez⁴  David R Willé⁵  Benson Singa⁶  Nhu Tran Do Hoang⁷  Tuyen Ha Thanh⁷  Phat Voong Vinh⁷  Stephen Baker⁸ 

[1] Department of Global Health, University of Washington, Seattle, United States;Department of Infectious Disease and Global Health, Tufts University Cummings School of Veterinary Medicine, North Grafton, United States;Division of Allergy and Infectious Disease, Center for Emerging and Re-emerging Infectious Diseases University of Washington School of Medicine, Seattle, United States;GSK Global Health, Tres Cantos, Madrid, Spain;GSK R&D, Stevenage, United Kingdom;Kenya Medical Research Institute, Nairobi, Kenya;The Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City, Viet Nam;University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, United Kingdom;

关键词: Shigella spp;    drug discovery;    multi-drug resistance;    dysentery;    diarrhoea;    carbapenems;   

DOI  :  10.7554/eLife.69798

来源: DOAJ

【 授权许可】

Unknown