Safety and Efficacy of Cell Transplantation on Improving Motor Symptoms in Patients With Parkinson’s Disease: A Meta-Analysis

Frontiers in Human Neuroscience

Yujun Hao¹  Zhaohai Feng¹  Yu Tian¹  Jiaming Wang¹  Lei Jiang¹  Xin Shi² 

[1] Department of Neurosurgery, First Affiliated Hospital of Xinjiang Medical University, Ürümqi, China;Department of Neurosurgery, Shenzhen University General Hospital and Shenzhen University Clinical Medical Academy Centre, Shenzhen University, Shenzhen, China;

关键词: Parkinson’s disease;    stem cells;    cell transplantation;    motor;    meta-analysis;   

DOI  :  10.3389/fnhum.2022.849069

来源: DOAJ

【 摘 要 】

BackgroundThe past four decades have seen the growing use of tissue or cell transplants in Parkinson’s disease (PD) treatment. Parkinson’s cell therapy is a promising new treatment; however, efficacy of cell transplantation for Parkinson’s disease are entirely unclear.ObjectiveTo conduct a meta-analysis and a systematic review of the efficacy of cell therapy in patients with PD.MethodsA systematic literature review and meta-analysis of 10 studies were performed to assess the efficacy of cell therapy in Parkinson’s patients. To achieve this, we compared the change in Unified Parkinson’s Disease Rating Scale (UPDRS) II and III scale scores to baseline and assessed the incidence of transplant-related adverse events. The MINORS score and the I2 index were applied to evaluate the quality of studies between-study heterogeneity, respectively.ResultsThe literature search yielded 10 articles (n = 120). The improvement in motor function based on the UPDRSIII assessment was −14.044 (95% CI: −20.761, −7.327) (p < 0.001), whereas improvement in daily living ability based on the UPDRSII assessment was −5.661 (95% CI: −7.632, −3.689) (p < 0.001).ConclusionThe present findings demonstrate important clues on the therapeutic effect of cell therapy in alleviating motor impairment and daily living ability in PD patients.

【 授权许可】

Unknown