Drosophila Heart as a Model for Cardiac Development and Diseases

Cells

Anissa Souidi¹  Krzysztof Jagla¹ 

[1] Genetics Reproduction and Development Institute (iGReD), INSERM U1103, CNRS UMR6293, University of Clermont Auvergne, 28 Place Henri-Dunant, 63000 Clermont-Ferrand, France;

关键词: heart;    cardiogenesis;    Drosophila melanogaster;    conduction defects;    arrhythmia;    congenital cardiomyopathy;   

DOI  :  10.3390/cells10113078

来源: DOAJ

【 摘 要 】

The Drosophila heart, also referred to as the dorsal vessel, pumps the insect blood, the hemolymph. The bilateral heart primordia develop from the most dorsally located mesodermal cells, migrate coordinately, and fuse to form the cardiac tube. Though much simpler, the fruit fly heart displays several developmental and functional similarities to the vertebrate heart and, as we discuss here, represents an attractive model system for dissecting mechanisms of cardiac aging and heart failure and identifying genes causing congenital heart diseases. Fast imaging technologies allow for the characterization of heartbeat parameters in the adult fly and there is growing evidence that cardiac dysfunction in human diseases could be reproduced and analyzed in Drosophila, as discussed here for heart defects associated with the myotonic dystrophy type 1. Overall, the power of genetics and unsuspected conservation of genes and pathways puts Drosophila at the heart of fundamental and applied cardiac research.

【 授权许可】

Unknown