Effect of a Dietary Supplement Combining Bioactive Peptides and Magnesium on Adjustment Disorder with Anxiety: A Clinical Trial in General Practice

Nutrients

Michel Besnier¹  Julie Akkoyun-Farinez²  Jeanne Cornet²  Frédéric Rouillon³  Sarah Oddoux⁴  Antoine Noël⁴  Paul Violette⁴ 

[1] Centre Médical Thémis, 50100 Cherbourg-en-Cotentin, France;Euraxi Pharma, 37300 Joué-lès-Tours, France;Hôpital Ste Anne, 75014 Paris, France;Laboratoire Dielen, 50110 Cherbourg-en-Cotentin, France;

关键词: anxiety;    stress;    bioactive peptide;    magnesium;    dietary supplement;   

DOI  :  10.3390/nu14122425

来源: DOAJ

【 摘 要 】

Anxiety is a high frequency disorder in the general population. It is usually treated with benzodiazepines, which cause side effects and a dependence that could make withdrawal difficult. Alternative treatments are therefore needed to reduce the use of anxiolytics, particularly for adjustment disorder with anxiety. An observational, multicentre, prospective, longitudinal study has been conducted by general practitioners and one gynaecologist to evaluate the efficacy of a dietary supplement on adjustment disorder with anxiety (Stress 2 study). Patients diagnosed as anxious with a score of ≥20 on the Hamilton Anxiety Rating Scale (Ham-A, first visit on Day 0 (V0)) were offered a 28-day treatment with a dietary supplement formulated with bioactive peptides from a fish protein hydrolysate (Gabolysat^®), magnesium and vitamin B6. At the second visit (V1), the Ham-A Rating Scale, the Patient Global Impression scale (PGI) and the Clinical Global Impressions scale (CGI) were administered. A 50% reduction in the Ham-A score, was achieved for 41.9% of the patients. The mean Ham-A score decreased by 12.1 ± 5.7 points (p < 0.001) between V0 (25.6 ± 3.8) and V1 (13.6 ± 6.0). Furthermore, according to the CGI scale, the anxiety of 75.3% of patients improved significantly and very significantly, with limited side effects and a negligible rebound effect. In conclusion, adjustment disorder with anxiety seems to be effectively managed by an alternative and safer solution than benzodiazepines.

【 授权许可】

Unknown