Special Report: The Biology of Inequalities in Health: The Lifepath Consortium

Frontiers in Public Health

Angelo D'Errico¹  Silvia Stringhini¹  Cristian Carmeli²  Roger L. Milne³  Graham Giles³  Peter Muennig⁴  Marcel Goldberg⁴  Michelle Kelly-Irving⁵  Wilma Nusselder⁵  Mika Kivimaki⁶  Thierry Lang⁷  Michael Marmot⁷  Johan P. Mackenbach⁸  Cathal McCrory⁹  Silvia Polidoro⁹  Dusan Petrovic^1,11  Fulvio Ricceri^1,12  Luca Carra^1,13  Cyrille Delpierre^1,14  Oliver Robinson^1,14  Mel Bartley^1,15  Paolo Vineis^1,16  Giuseppe Costa^1,16  Marie Zins^1,17  Mauricio Avendano-Pabon^1,18  Henrique Barros^1,19  Silvia Fraga^2,20  Frances MacGuire^2,20  Benoit Lepage^2,20  Richard Layte^2,20  Marc Chadeau-Hyam^2,21 

[1] Biology, Turin University Medical School, Turin, Italy;Public Health, University College London, London, United Kingdom;0Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, VIC, Australia;1Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, Australia;2Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Melbourne, VIC, Australia;3UMS 011 Inserm - UVSQ ≪ Cohortes épidémiologiques en population ≫, Villejuif, France;4Department of Epidemiology and Public Health, University College London, London, United Kingdom;5Department of Sociology, School of Social Sciences and Philosophy, Trinity College Dublin, Dublin, Ireland;6Department of Public Health, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands;7Department of Medical Gerontology, Trinity College Dublin, Dublin, Ireland;8Mailman School of Public Health, Columbia University, New York, NY, United States;9Molecular Epidemiology and Exposomics Unit, Italian Institute for Genomic Medicine, Turin, Italy;Center for Primary Care and Public Health (UNISANTE), University of Lausanne, Lausanne, Switzerland;;Department of Clinical Science &;Department of Epidemiology &Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom;Department of Epidemiology, ASL TO3, Turin, Italy;Department of Social Sciences, Health and Medicine, King's College London, London, United Kingdom;EPIUnit – Institute of Public Health University of Porto, Porto, Portugal;UMR LEASP, Université de Toulouse III, UPS, Inserm, Toulouse, France;Zadig, Milan, Italy;

关键词: social inequalities;    socioeconomic position;    healthy aging;    life-course;    omics;    biology;   

DOI  :  10.3389/fpubh.2020.00118

来源: DOAJ

【 摘 要 】

Funded by the European Commission Horizon 2020 programme, the Lifepath research consortium aimed to investigate the effects of socioeconomic inequalities on the biology of healthy aging. The main research questions included the impact of inequalities on health, the role of behavioral and other risk factors, the underlying biological mechanisms, the efficacy of selected policies, and the general implications of our findings for theories and policies. The project adopted a life-course and comparative approach, considering lifetime effects from childhood and adulthood, and pooled data on up to 1.7 million participants of longitudinal cohort studies from Europe, USA, and Australia. These data showed that socioeconomic circumstances predicted mortality and functional decline as strongly as established risk factors currently targeted by global prevention programmes. Analyses also looked at socioeconomically patterned biological markers, allostatic load, and DNA methylation using richly phenotyped cohorts, unraveling their association with aging processes across the life-course. Lifepath studies suggest that socioeconomic circumstances are embedded in our biology from the outset—i.e., disadvantage influences biological systems from molecules to organs. Our findings have important implications for policy, suggesting that (a) intervening on unfavorable socioeconomic conditions is complementary and as important as targeting well-known risk factors, such as tobacco and alcohol consumption, low fruit and vegetable intake, obesity and a sedentary lifestyle, and that (b) effects of preventive interventions in early life integrate interventions in adulthood. The report has an executive summary that refers to the different sections of the main paper.

【 授权许可】

Unknown