The Protective Effects of the Autophagic and Lysosomal Machinery in Vascular and Valvular Calcification: A Systematic Review

International Journal of Molecular Sciences

GuidoR. Y. De Meyer¹  CédricH. G. Neutel¹  JhanaO. Hendrickx¹  Wim Martinet¹  Pieter-Jan Guns¹ 

[1] Laboratory of Physiopharmacology, University of Antwerp, 2610 Antwerp, Belgium;

关键词: vascular calcification;    aortic valve calcification;    autophagy;    lysosomes;    vascular smooth muscle cell (VSMC);    valvular interstitial cell (VIC);   

DOI  :  10.3390/ijms21238933

来源: DOAJ

【 摘 要 】

Background: Autophagy is a highly conserved catabolic homeostatic process, crucial for cell survival. It has been shown that autophagy can modulate different cardiovascular pathologies, including vascular calcification (VCN). Objective: To assess how modulation of autophagy, either through induction or inhibition, affects vascular and valvular calcification and to determine the therapeutic applicability of inducing autophagy. Data sources: A systematic review of English language articles using MEDLINE/PubMed, Web of Science (WoS) and the Cochrane library. The search terms included autophagy, autolysosome, mitophagy, endoplasmic reticulum (ER)-phagy, lysosomal, calcification and calcinosis. Study characteristics: Thirty-seven articles were selected based on pre-defined eligibility criteria. Thirty-three studies (89%) studied vascular smooth muscle cell (VSMC) calcification of which 27 (82%) studies investigated autophagy and six (18%) studies lysosomal function in VCN. Four studies (11%) studied aortic valve calcification (AVCN). Thirty-four studies were published in the time period 2015–2020 (92%). Conclusion: There is compelling evidence that both autophagy and lysosomal function are critical regulators of VCN, which opens new perspectives for treatment strategies. However, there are still challenges to overcome, such as the development of more selective pharmacological agents and standardization of methods to measure autophagic flux.

【 授权许可】

Unknown