Firing up the Tumor Microenvironment with Nanoparticle-Based Therapies

Pharmaceutics

Jia Wei¹  Xueru Song¹  Yunfeng Pan¹  Yue Wang¹ 

[1] The Comprehensive Cancer Centre of Drum Tower Hospital, Medical School of Nanjing University & Clinical Cancer Institute of Nanjing University, Nanjing 210008, China;

关键词: nanoparticle;    immunotherapy;    tumor microenvironment;    cancer vaccine;    adoptive cell therapy;   

DOI  :  10.3390/pharmaceutics13091338

来源: DOAJ

【 摘 要 】

Therapies mobilizing host immunity against cancer cells have profoundly improved prognosis of cancer patients. However, efficacy of immunotherapies depends on local immune conditions. The “cold” tumor, which is characterized by lacking inflamed T cells, is insensitive to immunotherapy. Current strategies of improving the “cold” tumor microenvironment are far from satisfying. Nanoparticle-based therapies provide novel inspiration in firing up the tumor microenvironment. In this review, we presented progress and limitations of conventional immunotherapies. Then, we enumerate advantages of nanoparticle-based therapies in remodeling the “cold” tumor microenvironment. Finally, we discuss the prospect of nanoparticle-based therapies in clinical application.

【 授权许可】

Unknown