The Causes and Consequences of miR-503 Dysregulation and Its Impact on Cardiovascular Disease and Cancer

Frontiers in Pharmacology

Zhengyuan Xia¹  Yanjing He²  Yin Cai³  Pearl Mingchu Pai⁴  Xinling Ren⁶ 

[1] Department of Anesthesiology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China;Department of Anesthesiology, The University of Hong Kong, Hong Kong, China;Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hong Kong, China;Department of Medicine, The University of Hong Kong - Queen Mary Hospital, Hong Kong, China;Department of Medicine, The University of Hong Kong - Shenzhen Hospital, Shenzhen, China;Department of Respiratory Medicine, Shenzhen University General Hospital, Shenzhen, China;State Key Laboratory of Pharmaceutical Biotechnology, Department of Medicine, The University of Hong Kong, Hong Kong, China;

关键词: microRNAs;    microRNA-503;    cardiovascular disease;    cancer;    angiogenesis;    oxidative stress;   

DOI  :  10.3389/fphar.2021.629611

来源: DOAJ

【 摘 要 】

microRNAs (miRs) are short, non-coding RNAs that regulate gene expression by mRNA degradation or translational repression. Accumulated studies have demonstrated that miRs participate in various biological processes including cell differentiation, proliferation, apoptosis, metabolism and development, and the dysregulation of miRs expression are involved in different human diseases, such as neurological, cardiovascular disease and cancer. microRNA-503 (miR-503), one member of miR-16 family, has been studied widely in cardiovascular disease and cancer. In this review, we summarize and discuss the studies of miR-503 in vitro and in vivo, and how miR-503 regulates gene expression from different aspects of pathological processes of diseases, including carcinogenesis, angiogenesis, tissue fibrosis and oxidative stress; We will also discuss the mechanisms of dysregulation of miR-503, and whether miR-503 could be applied as a diagnostic marker or therapeutic target in cardiovascular disease or cancer.

【 授权许可】

Unknown