Serum Brain-Derived Neurotrophic Factor, and Plasma Catecholamine Metabolites in People with Major Depression: Preliminary Cross-Sectional Study

Frontiers in Psychiatry

Taro Kishi¹  Nakao Iwata¹  Reiji Yoshimura²  Asuka Katsuki²  Kiyokazu Atake² 

[1] Department of Psychiatry, School of Medicine, Fujita Health University, Toyoake, Japan;Department of Psychiatry, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan;

关键词: 3-methoxy-4-hydroxyphenylglycol;    homovanillic acid;    brain-derived neurotrophic factor;    major depression;    serum;    plasma;   

DOI  :  10.3389/fpsyt.2018.00052

来源: DOAJ

【 摘 要 】

BackgroundThere are complicated interactions between catecholaminergic neurons and brain-derived neurotrophic factor (BDNF) in the brain. However, no reports have addressed the relationship among 3-methoxy-4-hydroxyphenylglycol (MHPG), homovanillic acid (HVA), and BDNF in the blood.ObjectiveThis paper sought to investigate correlations between serum BDNF and plasma levels of MHPG and HVA in people with major depression (MD).Materials and methodsA total of 148 patients (male/female 65/83, age 49.5 ± 12.1 years old) who satisfied criteria for MD based on the Diagnostic and Statistical Manual of Mental Disorders IV were enrolled in the present study. Plasma levels of MHPG and HVA were analyzed using high-performance liquid chromatography, and serum BDNF was measured using ELISA.ResultsNo interactions were observed between plasma HVA levels (mean ± SD = 4.5 ± 1.5 ng/mL) and age, sex, HAMD scores, or serum BDNF levels (mean ± SD = 9.8 ± 2.9 ng/mL). No correlations were not also observed between plasma MHPG levels (mean ± SD = 5.9 ± 2.1 ng/mL) and age, sex, the HAMD17 scores (mean ± SD = 22.2 ± 2.9 ng/mL), or serum BDNF levels. Serum BDNF levels were negatively associated with HAMD17 scores.ConclusionThe results suggest that there are no significant correlations between catecholamine metabolites and BDNF in the blood for MDD patients.

【 授权许可】

Unknown