Intraoperative radiation therapy induces immune response activity after pancreatic surgery

BMC Cancer

Ik Jae Lee¹  Yeona Cho¹  Hyo Jung Kim²  Joon Seong Park²  Yun Sun Lee²  Hyeon Woong Kang²  Hyung Sun Kim²  Da Eun Lee² 

[1] Department of Radiation Oncology, Yonsei University College of Medicine;Department of Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine;

关键词: Pancreatic cancer;    Intraoperative radiation therapy;    Immune response;    Cytokine;   

DOI  :  10.1186/s12885-021-08807-3

来源: DOAJ

【 摘 要 】

Abstract Background Pancreatic cancer has highly aggressive features, such as local recurrence that leads to significantly high morbidity and mortality and recurrence after successful tumour resection. Intraoperative radiation therapy (IORT), which delivers targeted radiation to a tumour bed, is known to reduce local recurrence by directly killing tumour cells and modifying the tumour microenvironment. Methods Among 30 patients diagnosed with pancreatic cancer, 17 patients received IORT immediately after surgical resection. We investigated changes in the immune response induced by IORT by analysing the peritoneal fluid (PF) and blood of patients with and without IORT treatment after pancreatic cancer surgery. Further, we treated three pancreatic cell lines with PF to observe proliferation and activity changes. Results Levels of cytokines involved in the PI3K/SMAD pathway were increased in the PF of IORT-treated patients. Moreover, IORT-treated PF inhibited the growth, migration, and invasiveness of pancreatic cancer cells. Changes in lymphocyte populations in the blood of IORT-treated patients indicated an increased immune response. Conclusions Based on the characterisation and quantification of immune cells in the blood and cytokine levels in the PF, we conclude that IORT induced an anti-tumour effect by activating the immune response, which may prevent pancreatic cancer recurrence. Clinical trial registration NCT03273374 .

【 授权许可】

Unknown