Genomic Analyses Reveal the Influence of Geographic Origin, Migration, and Hybridization on Modern Dog Breed Development

Cell Reports

Dayna L. Dreger¹  Alexandra B. Mullen¹  Elaine A. Ostrander¹  Brian W. Davis¹  Maud Rimbault¹  Gretchen Carpintero-Ramirez¹  Heidi G. Parker¹ 

[1] Cancer Genetics and Comparative Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA;

关键词: canine;    domestication;    population;    migration;    morphology;    behavior;    admixture;   

DOI  :  10.1016/j.celrep.2017.03.079

来源: DOAJ

【 摘 要 】

There are nearly 400 modern domestic dog breeds with a unique histories and genetic profiles. To track the genetic signatures of breed development, we have assembled the most diverse dataset of dog breeds, reflecting their extensive phenotypic variation and heritage. Combining genetic distance, migration, and genome-wide haplotype sharing analyses, we uncover geographic patterns of development and independent origins of common traits. Our analyses reveal the hybrid history of breeds and elucidate the effects of immigration, revealing for the first time a suggestion of New World dog within some modern breeds. Finally, we used cladistics and haplotype sharing to show that some common traits have arisen more than once in the history of the dog. These analyses characterize the complexities of breed development, resolving longstanding questions regarding individual breed origination, the effect of migration on geographically distinct breeds, and, by inference, transfer of trait and disease alleles among dog breeds.

【 授权许可】

Unknown