Polydopamine-Based Nanocarriers for Photosensitizer Delivery

Frontiers in Chemistry

Yuxuan Xiong³  Zushun Xu³  Zifu Li⁵ 

[1] Department of Nanomedicine and Biopharmaceuticals, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China;Hubei Key Laboratory of Bioinorganic Chemistry and Materia Medica, Huazhong University of Science and Technology, Wuhan, China;Key Laboratory for the Green Preparation and Application of Functional Materials, Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials, Ministry of Education, Hubei University, Wuhan, China;National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China;Wuhan Institute of Biotechnology, East Lake High Tech Zone, Wuhan, China;

关键词: polydopamine;    photosensitizers;    drug delivery;    photodynamic therapy;    nanocarriers;   

DOI  :  10.3389/fchem.2019.00471

来源: DOAJ

【 摘 要 】

Photodynamic therapy (PDT) has emerged as a non-invasive modality for treating tumors while a photosensitizer (PS) plays an indispensable role in PDT. Nevertheless, free PSs are limited by their low light stability, rapid blood clearance, and poor water solubility. Constructing a nanocarrier delivering PSs is an appealing and potential way to solve these issues. As a melanin-like biopolymer, polydopamine (PDA) is widely utilized in biomedical applications (drug delivery, tissue engineering, and cancer therapy) for its prominent properties, including favorable biocompatibility, easy preparation, and versatile functionality. PDA-based nanocarriers are thus leveraged to overcome the inherent shortcomings of free PSs. In this Mini-Review, we will firstly present an overview on the recent developments of PDA nanocarriers delivering PSs. Then, we introduce three distinctive strategies developed to combine PSs with PDA nanocarriers. The advantages and disadvantages of each strategy will be discussed. Finally, the current challenges and future opportunities of PDA-based PS nanocarriers will also be addressed.

【 授权许可】

Unknown