Oyster hydrolysate-zinc complex ameliorates carrageenan-induced rat prostatitis via an anti-inflammatory mechanism and reduced oxidative stress

Journal of Functional Foods

Mingyong Zeng¹  Suisui Jiang²  Shiyang Li²  Yinong Feng²  Zunying Liu²  Zhe Wang³ 

[1] Corresponding authors.;College of Food Science and Engineering, Ocean University of China, 5 Yushan Road, Qingdao, Shandong Province 266003, China;Department of Clinical Laboratory, The Affiliated Hospital of Qingdao University, Qingdao, Shandong Province 266000, China;

关键词: Nonbacterial prostatitis;    Oyster hydrolysates;    Hydrolysate-zinc complex;    Zinc intake;    Amelioration effect;   

DOI  :  

来源: DOAJ

【 摘 要 】

Nonbacterial prostatitis has been reported to be associated with reduced zinc intake, but the role of zinc remains unclear. Here, oyster hydrolysate-zinc complex (OH-Zn) was prepared to attenuate rat prostatitis. We found using dynamic light scattering and energy-dispersive X-ray analysis that OH-Zn was a nanostructure complex (49.06 ± 0.26 nm) with a prominent signal of zinc. Fourier transform infrared spectroscopy illustrated that OH-Zn was formed via interactions among zinc ions, amino nitrogen atoms and carboxyl oxygen. OH-Zn treatment significantly reduced the prostatic index value, prostatic specific antigen, tumor necrosis factor-alpha, interleukin-1 beta, malonaldehyde, prostatic acid phosphatase, and acid phosphatase in prostatitis rats. OH-Zn increased the levels of superoxide dismutase, glutathione and serum zinc concentration in prostatitis rats relative to the control group. Moreover, histological analyses revealed OH-Zn prevented the carrageen-induced pathological morphology of the prostate. Therefore, OH-Zn might be a preferable paradigm to ameliorate prostatitis as a novel zinc supplement.

【 授权许可】

Unknown