Hypoglycaemic, insulin releasing, and hepatoprotective effect of the aqueous extract of Aloe perryi Baker resin (Socotran Aloe) in streptozotocin-induced diabetic rats

Journal of Taibah University for Science

Mary H. Grace¹  Ulfat Mohammed Omar²  Ghedeir M. Alshammari³  Mohammed A. Yahya⁴  Mary Ann Lila⁴  Tahany Saleh Aldayel⁵ 

[1] Immunology Unit, King Fahad Medical Research Center;King Abdulaziz University;King Saud University;North Carolina State University, North Carolina Research Campus;Princess Nourah Bint Abdulrahman University;

关键词: aloe perryi;    polyphenols;    anti-diabetic;    anti-hyperlipidemia;    alt;    ast;   

DOI  :  10.1080/16583655.2020.1855859

来源: DOAJ

【 摘 要 】

This study evaluated the anti-diabetic and hepatic protective effect of the aqueous extract of the Aloe perryi (AP) in streptozotocin-induced diabetic rats. Rat were divided into control, diabetic, diabetic + glimepiride, diabetic + AP (150 or 300 mg/Kg) groups. AP (300 mg/Kg) alone lowered fasting serum glucose levels but increased insulin levels and HOMA-β. At both doses, AP significantly decreased hepatic levels of CHOL and LDL-C and reduced serum levels of TGs, CHOL, and LDL-C, without altering levels of HDL-C in the diabetic rats. Also, they improved liver architectures and reduced serum levels of ALT and AST. Concomitantly, they suppressed hepatic levels of MDA, and increase hepatic levels of SOD, GSH, CAT, and GPx. Except for lipids, the effect of the extract on all other parameters was more profound with the higher dose of the extract. In conclusion, AP extract exerts hypoglycaemic, insulin-releasing, and hepatic antioxidant potentials in diabetic rats.

【 授权许可】

Unknown