Adiponectin Associates with Rheumatoid Arthritis Risk in Overweight and Obesity Independently of Other Adipokines

Journal of Clinical Medicine

Johanna Andersson-Assarsson¹  Lena Carlsson¹  Magdalena Taube¹  Per-Arne Svensson¹  Cristina Maglio²  Anna Rudin²  Yuan Zhang²  Christian Herder³  Markku Peltonen⁴  Linda Johansson⁵  Solbritt Rantapää-Dahlqvist⁵ 

[1] Department of Molecular and Clinical Medicine, Sahlgrenska Academy, University of Gothenburg, SE-41345 Gothenburg, Sweden;Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, SE-40530 Gothenburg, Sweden;Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research, Heinrich-Heine University Duesseldorf, 40225 Duesseldorf, Germany;Public Health Promotion Unit, National Institute for Health and Welfare, FI-00271 Helsinki, Finland;Public Health and Clinical Medicine/Rheumatology, Umeå University, SE-90587 Umeå, Sweden;

关键词: adiponectin;    adipokines;    rheumatology;    obesity;    overweight;    case control study;   

DOI  :  10.3390/jcm10132791

来源: DOAJ

【 摘 要 】

We recently reported that increased serum adiponectin was associated with rheumatoid arthritis (RA) risk in subjects with obesity. We hereby aim to determine if other adipokines associate with RA risk and if the association between adiponectin and RA is independent of other adipokines. Two nested-case control studies were performed in two different cohorts: 82 participants of the Swedish Obese Subjects (SOS) study who developed RA during follow-up matched with 410 controls, and 88 matched pairs from the Medical Biobank of Northern Sweden. Baseline levels of circulating adipokines were measured using ELISA. In a multivariable analysis in the SOS cohort, higher adiponectin was associated with an increased risk of RA independently of other adipokines (OR for RA risk: 1.06, 95% CI: 1.01–1.12, p = 0.02). No association between leptin, resistin, and visfatin levels and the risk of RA was detected. In the cohort from the Medical Biobank of Northern Sweden, higher adiponectin was associated with an increased risk of RA only in participants with overweight/obesity (OR: 1.17, 95% CI: 1.01−1.36, p = 0.03), independently of other adipokines. Our results show that in individuals with overweight/obesity, higher circulating levels of adiponectin, but not leptin, resistin, or visfatin, were associated with an increased RA risk.

【 授权许可】

Unknown