The Effect of Maternal Age at the First Childbirth on Gestational Age and Birth Weight: The Japan Environment and Children’s Study (JECS)

Journal of Epidemiology

the Japan Environment and Children’s Study (JECS) Group¹  Hyo Kyozuka²  Keiya Fujimori²  Seiji Yasumura²  Tadahiko Yokoyama²  Mitsuaki Hosoya²  Akiko Sato²  Koichi Hashimoto² 

[1] ;Fukushima Regional Center for the Japan Environmental and Children’s Study, Fukushima, Japan;

关键词: maternal age;    preterm birth;    first delivery;    low birth weight;    birth cohort study;   

DOI  :  10.2188/jea.JE20170283

来源: DOAJ

【 摘 要 】

Background: In Japan, mean maternal age at first childbirth is increasing. The aim of this study was to investigate whether maternal age at the first childbirth is a risk factor for preterm birth (PTB), low birth weight (LBW), and small for gestational age (SGA). Methods: We used the results of Japan Environment and Children’s Study (JECS) who gave birth in 2011–2014. Cases of primiparous singleton pregnancies where the subject was ≥20 years and delivered after 22 weeks were included. All subjects were categorized into five groups according to maternal age: 20–24, 25–29, 30–34, 35–39, and ≥40 years. Adjusted odds ratios (aORs) for PTB (before 37 and 34 weeks), LBW (<2,500 g and <1,500 g), and SGA were calculated using a logistic regression model, with the 20–24-year age group as reference. Results: We analyzed 38,412 singleton primiparous pregnancies. The aORs of all outcomes increased in parallel with each maternal age group >30 years. The aORs of PTB before 37 and 34 weeks, LBW <2,500 g, LBW <1,500 g, and SGA in the 30–34-year age group were 1.39 (95% confidence interval [CI], 1.16–1.67), 2.23 (95% CI, 1.45–3.41), 1.34 (95% CI, 1.18–1.53), 2.30 (95% CI, 1.35–3.94), and 1.24 (95% CI, 1.05–1.46), respectively. Conclusion: The present study showed that higher maternal age (>30 years) at the first childbirth was an independent risk factor for PTB, LBW, and SGA.

【 授权许可】

Unknown