Epidermal Growth Factor Pathway Signaling in Drosophila Embryogenesis: Tools for Understanding Cancer

Cancers

Vanessa Y. M. Lam¹  Jay B. Lusk¹  Nicholas S. Tolwinski¹ 

[1] Division of Science, Yale-NUS College, Singapore 138527, Singapore;

关键词: EGF signaling;    Drosophila development;    RAS;    RAF;    MAP kinase;    MEK;   

DOI  :  10.3390/cancers9020016

来源: DOAJ

【 摘 要 】

EGF signaling is a well-known oncogenic pathway in animals. It is also a key developmental pathway regulating terminal and dorsal-ventral patterning along with many other aspects of embryogenesis. In this review, we focus on the diverse roles for the EGF pathway in Drosophila embryogenesis. We review the existing body of evidence concerning EGF signaling in Drosophila embryogenesis focusing on current uncertainties in the field and areas for future study. This review provides a foundation for utilizing the Drosophila model system for research into EGF effects on cancer.

【 授权许可】

Unknown