Enterovirus Transmission by Secretory Autophagy

Viruses

Nihal Altan-Bonnet¹  Yael Mutsafi¹ 

[1] Laboratory of Host-Pathogen Dynamics, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA;

关键词: secretory autophagy;    picornavirus;    enterovirus;    poliovirus;    Coxsackievirus;    rhinovirus;    syntaxin 17;    viral transmission;    quasispecies;    RNA virus;   

DOI  :  10.3390/v10030139

来源: DOAJ

【 摘 要 】

Present in many cell types, non-degradative secretory autophagy is a newly discovered pathway in which autophagosomes fuse with the plasma membrane instead of lysosomes. Surprisingly, some viruses exploit secretory autophagy to exit cells non-lytically, shedding into the extracellular environment as particle populations contained within vesicles. As a result, this significantly enhances the infectivity of these viruses. In this paper, this novel cellular exit pathway is highlighted and its advantages for viral transmission discussed.

【 授权许可】

Unknown