NOVEL ULTRAVIOLET ABSORBERS DERIVED FROM CASHEW NUT SHELL LIQUID: SPECTROPHOTOMETRIC, IN SILICO AND IN VITRO ASSAYS

Drug Analytical Research

Ana Paula Rodrigues¹  Priscilla Souza Alves²  Viviane Cândida da Silva²  Emeli Moura de Araújo³  Sheila Garcia⁴  Gisela Maria Dellamora-Ortiz⁴  Maria Márcia Murta⁵  Luiz Antônio Soares Romeiro⁵  Álvaro Augusto da Costa Leitão⁵  Maria Lucília dos Santos⁵  Lúcio Paulo Lima Logrado⁵ 

[1] Universidade Católica de Brasília;Universidade Católica de Brasília;Universidade Federal Fluminense;Universidade Federal do Rio de Janeiro;Universidade de Brasília;

关键词: ultraviolet absorbers;    cashew nut;    spf;    spectrophotometry;   

DOI  :  https://doi.org/10.22456/2527-2616.108405

来源: DOAJ

【 摘 要 】

The cashew nut shell liquid (CNSL) constituents were isolated by our group leading to four mixtures and seventeen pure compounds, which had chromophoric groups similar to organic ultraviolet (UV) absorbers. In addition, C15 and C8 CNSL-derivatives molecules were rationally planned as UV absorbers. Mixtures and isolated CNSL compounds were demonstrated to be non-phototoxic when evaluated in a phototoxicity assay using the yeast Saccharomyces cerevisiae. Considering the absorption values on the UV range, 6 compounds showed appropriate SPF values regarding the spectrophotometric test. Additionally, in silico and in vitro evaluations were performed, showing non-oral bioavailability, as well as non-mutagenic, non-genotoxic and non-phototoxic properties for the tested compounds. These results contribute favorably to the aimed use of the compounds under analysis as novel organic UV absorbers that have as precursor the phenolic lipid component of CNSL, a waste product obtained as the by-product of cashew nut food processing.

【 授权许可】

Unknown