Recent progress in orexin/hypocretin physiology and pharmacology

Biomolecular Concepts

Kukkonen Jyrki P.¹ 

[1] Biochemistry and Cell Biology, Department of Veterinary Biosciences, FIN-00014 University of Helsinki, Finland;

关键词: g-protein-coupled receptor;    hypocretin;    neuropeptide;    orexin;    orexin receptor;   

DOI  :  10.1515/bmc-2012-0013

来源: DOAJ

【 摘 要 】

Orexin peptides and their cognate receptors were discovered 14 years ago. They soon took a very central position in the regulation of sleep and wakefulness. Active studies have further elucidated these functions as well as the role of orexins in, for instance, appetite, metabolism, analgesia, addiction, and stress response. This review summarizes all the important fields but especially aims at focusing on novel findings and future directions.

【 授权许可】

Unknown