Can attractor network models account for the statistics of firing during persistent activity in prefrontal cortex?

Frontiers in Neuroscience

Francesca Barbieri²  Nicolas Brunel³ 

[1] CNRS UMR 8119;ISI Foundation;Laboratoire de Neurophysique et Physiologie, Université Paris Descartes;

关键词: Prefrontal Cortex;    working memory;    network models;    integrate-and-fire;    short-term depression;   

DOI  :  10.3389/neuro.01.003.2008

来源: DOAJ

【 摘 要 】

Persistent activity observed in neurophysiological experiments in monkeys is thought to be the neuronal correlate of working memory. Over the last decade, network modellers have strived to reproduce the main features of these experiments. In particular, attractor network models have been proposed in which there is a coexistence between a non-selective attractor state with low background activity with selective attractor states in which sub-groups of neurons fire at rates which are higher (but not much higher) than background rates.A recent detailed statistical analysis of the data seems however to challenge such attractor models: the data indicates that firing during persistent activity is highly irregular (with an average CV larger than 1), while models predict a more regular firing process (CV smaller than 1). We discuss here recent proposals that allow to reproduce this feature of the experiments.

【 授权许可】

Unknown