Probiotics: A Promising Candidate for Management of Colorectal Cancer

Cancers

Ashutosh Tripathy¹  Deviyani Mahajan¹  Manoj Kumar Jena¹  Sudhakar Kancharla²  Prachetha Kolli³  Shantibhusan Senapati⁴  Jayalaxmi Dash⁴ 

[1] Department of Biotechnology, School of Bioengineering and Biosciences, Lovely Professional University, Phagwara, Punjab 144411, India;Devansh Lab Werks, 234 Aquarius Drive, Homewood, AL 35209, USA;Microgen Health Inc., 14225 Sullyfield Cir Suite E, Chantilly, VA 20151, USA;Tumor Microenvironment and Animal Models Laboratory, Institute of Life Sciences, Bhubaneswar, Odisha 751023, India;

关键词: probiotics;    colorectal cancer;    inflammatory bowel disease;    immunomodulation;    intestinal barrier function;    apoptosis;   

DOI  :  10.3390/cancers13133178

来源: DOAJ

【 摘 要 】

Colorectal cancer (CRC) is the World’s third most frequently diagnosed cancer type. It accounted for about 9.4% mortality out of the total incidences of cancer in the year 2020. According to estimated facts by World Health Organization (WHO), by 2030, 27 million new CRC cases, 17 million deaths, and around 75 million people living with the disease will appear. The facts and evidence that establish a link between the intestinal microflora and the occurrence of CRC are quite intuitive. Current shortcomings of chemo- and radiotherapies and the unavailability of appropriate treatment strategies for CRC are becoming the driving force to search for an alternative approach for the prevention, therapy, and management of CRC. Probiotics have been used for a long time due to their beneficial health effects, and now, it has become a popular candidate for the preventive and therapeutic treatment of CRC. The probiotics adopt different strategies such as the improvement of the intestinal barrier function, balancing of natural gut microflora, secretion of anticancer compounds, and degradation of carcinogenic compounds, which are useful in the prophylactic treatment of CRC. The pro-apoptotic ability of probiotics against cancerous cells makes them a potential therapeutic candidate against cancer diseases. Moreover, the immunomodulatory properties of probiotics have created interest among researchers to explore the therapeutic strategy by activating the immune system against cancerous cells. The present review discusses in detail different strategies and mechanisms of probiotics towards the prevention and treatment of CRC.

【 授权许可】

Unknown