Immunotherapy for Refractory Autoimmune Encephalitis

Frontiers in Immunology

关键词: autoimmune encephalitis;    refractory;    third-line therapy;    rituximab;    neuroimmunology;   

DOI  :  10.3389/fimmu.2021.790962

来源: DOAJ

【 摘 要 】

Autoimmune encephalitis (AE) is an immune-mediated disease involving the central nervous system, usually caused by antigen-antibody reactions. With the advent of autoantibody-associated diseases, AE has become a hot research frontier in neuroimmunology. The first-line conventional treatments of autoimmune encephalitis consist of steroids, intravenous immunoglobulin (IVIG), plasma exchange (PLEX), and second-line therapy includes rituximab. Despite considerable research and expanding clinical experience, current treatments are still ineffective for a significant number of patients. Although there is no clear consensus, clinical trial evidence limited, and the level of evidence for some of the drugs based on single reports, third-line therapy is a viable alternative for refractory encephalitis patients. With the current rapid research progress, a breakthrough in the treatment of AE is critical. This article aims to review the third-line therapy for refractory AE

【 授权许可】

Unknown