ESC Heart Failure | |
The multiple faces of autoimmune/immune‐mediated myocarditis in children: a biopsy‐proven case series treated with immunosuppressive therapy | |
Stefania Rizzo1  Cristina Basso1  Anna Baritussio2  Alida L.P. Caforio2  Renzo Marcolongo3  Elena Reffo4  Alessia Cerutti4  Giovanni Di Salvo4  Biagio Castaldi4  | |
[1] Cardiovascular Pathology Unit, Department of Cardiac, Thoracic, Vascular Sciences and Public Health University of Padova Padova Italy;Division of Cardiology, Department of Cardiac Thoracic Vascular Sciences and Public Health University of Padova Padova Italy;Hematology and Clinical Immunology, Department of Medicine University of Padova Padova Italy;Pediatric Cardiology, Department of Woman and Child Health University of Padova Padova Italy; | |
关键词: Myocarditis; Immunosuppressive therapy; Children; Endomyocardial biopsy; | |
DOI : 10.1002/ehf2.13163 | |
来源: DOAJ |
【 摘 要 】
Abstract The role of immunosuppressive therapy (IT) in paediatric autoimmune/immune‐mediated myocarditis remains poorly defined. To explore its role, we present a series of three consecutive paediatric patients with biopsy‐proven, virus negative, autoimmune/immune‐mediated myocarditis, with distinct clinical and pathological features, who have been successfully treated with IT, a 14‐year‐old boy with Loeffler's fibroblastic parietal endomyocarditis, a 6‐year‐old child with celiac disease with chronic active lymphocytic myocarditis, and a 13‐year‐old boy with long‐standing heart failure and active lymphocytic myocarditis. Patients started IT and entered follow‐up between July 2017 and September 2019; the first patient completed IT. IT was associated with a substantial and sustained recovery of cardiac function in our patients, regardless of their heterogeneous clinical and pathological features. Combination IT was well tolerated and enabled tapering and weaning off steroids.
【 授权许可】
Unknown