The multiple faces of autoimmune/immune‐mediated myocarditis in children: a biopsy‐proven case series treated with immunosuppressive therapy

ESC Heart Failure

Stefania Rizzo¹  Cristina Basso¹  Anna Baritussio²  Alida L.P. Caforio²  Renzo Marcolongo³  Elena Reffo⁴  Alessia Cerutti⁴  Giovanni Di Salvo⁴  Biagio Castaldi⁴ 

[1] Cardiovascular Pathology Unit, Department of Cardiac, Thoracic, Vascular Sciences and Public Health University of Padova Padova Italy;Division of Cardiology, Department of Cardiac Thoracic Vascular Sciences and Public Health University of Padova Padova Italy;Hematology and Clinical Immunology, Department of Medicine University of Padova Padova Italy;Pediatric Cardiology, Department of Woman and Child Health University of Padova Padova Italy;

关键词: Myocarditis;    Immunosuppressive therapy;    Children;    Endomyocardial biopsy;   

DOI  :  10.1002/ehf2.13163

来源: DOAJ

【 摘 要 】

Abstract The role of immunosuppressive therapy (IT) in paediatric autoimmune/immune‐mediated myocarditis remains poorly defined. To explore its role, we present a series of three consecutive paediatric patients with biopsy‐proven, virus negative, autoimmune/immune‐mediated myocarditis, with distinct clinical and pathological features, who have been successfully treated with IT, a 14‐year‐old boy with Loeffler's fibroblastic parietal endomyocarditis, a 6‐year‐old child with celiac disease with chronic active lymphocytic myocarditis, and a 13‐year‐old boy with long‐standing heart failure and active lymphocytic myocarditis. Patients started IT and entered follow‐up between July 2017 and September 2019; the first patient completed IT. IT was associated with a substantial and sustained recovery of cardiac function in our patients, regardless of their heterogeneous clinical and pathological features. Combination IT was well tolerated and enabled tapering and weaning off steroids.

【 授权许可】

Unknown