Clinical and Cytokine Profile in Patients with Early and Late Onset Meniere Disease

Journal of Clinical Medicine

Juan Antonio Gallego¹  Ismael Aran²  Emilio Dominguez-Durán³  Maria Alharilla Montilla-Ibañez⁴  Andres Soto-Varela⁵  Estrella Martinez-Gomez⁶  Marisa Flook⁶  Jose A. Lopez-Escamez⁶  Maria-Del-Carmen Moleon⁶  Lidia Frejo⁶  Andreina Peralta-Leal⁶  Hortensia Sanchez-Gomez⁷ 

[1] Department of Neurology, Hospital Universitario Virgen de las Nieves, Universidad de Granada, 18014 Granada, Spain;Department of Otolaryngology, Complexo Hospitalario de Pontevedra, 36071 Pontevedra, Spain;Department of Otolaryngology, Hospital Virgen Macarena, 41009 Sevilla, Spain;Department of Otorhinolaryngology, Complejo Hospitalario de Jaén, 23007 Jaen, Spain;Division of Neurotology, Department of Otorhinolaryngology, Complexo Hospitalario Universitario, 15706 Santiago de Compostela, Spain;Otology and Neurotology Group CTS495, Department of Genomic Medicine, GENYO—Centre for Genomics and Oncological Research—Pfizer/University of Granada/Junta de Andalucía, PTS, 18016 Granada, Spain;Otoneurology Unit, Department of Otorhinolaryngology, University Hospital of Salamanca, IBSAL, 37007 Salamanca, Spain;

关键词: hearing loss;    vertigo;    migraine;    cytokines;    inflammation;    vestibular disorders;   

DOI  :  10.3390/jcm10184052

来源: DOAJ

【 摘 要 】

Background: Meniere disease (MD) is an inner ear disorder associated with comorbidities such as autoimmune diseases or migraine. This study describes clinical and cytokine profiles in MD according to the age of onset of the condition. Methods: A cross-sectional study including 83 MD patients: 44 with early-onset MD (EOMD, <35 years old), and 39 with late-onset MD (LOMD, >50 years old), 64 patients with migraine and 55 controls was carried out. Clinical variables and cytokines levels of CCL3, CCL4, CCL18, CCL22, CXCL,1 and IL-1β were compared among the different groups. Results: CCL18 levels were higher in patients with migraine or MD than in controls. Elevated levels of IL-1β were observed in 11.4% EOMD and in 10.3% LOMD patients and these levels were not dependent on the age of individuals. EOMD had a longer duration of the disease (p = 0.004) and a higher prevalence of migraine than LOMD (p = 0.045). Conclusions: Patients with EOMD have a higher prevalence of migraine than LOMD, but migraine is not associated with any cytokine profile in patients with MD. The levels of CCL18, CCL3, and CXCL4 were different between patients with MD or migraine and controls.

【 授权许可】

Unknown