Metabolic reprogramming in triple-negative breast cancer

Cancer Biology & Medicine

Qianjin Jiang¹  Chenfang Dong²  Zhanyu Wang² 

[1] Department of Pathology and Pathophysiology, Zhejiang University School of Medicine, Hangzhou 310058, China;Department of Surgical Oncology (Breast Center) of The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China;

关键词: metabolic reprogramming;    triple-negative breast cancer;    aerobic glycolysis;    warburg effect;    cancer stem cell;    targeted therapy;   

DOI  :  10.20892/j.issn.2095-3941.2019.0210

来源: DOAJ

【 摘 要 】

Since triple-negative breast cancer (TNBC) was first defined over a decade ago, increasing studies have focused on its genetic and molecular characteristics. Patients diagnosed with TNBC, compared to those diagnosed with other breast cancer subtypes, have relatively poor outcomes due to high tumor aggressiveness and lack of targeted treatment. Metabolic reprogramming, an emerging hallmark of cancer, is hijacked by TNBC to fulfill bioenergetic and biosynthetic demands; maintain the redox balance; and further promote oncogenic signaling, cell proliferation, and metastasis. Understanding the mechanisms of metabolic remodeling may guide the design of metabolic strategies for the effective intervention of TNBC. Here, we review the metabolic reprogramming of glycolysis, oxidative phosphorylation, amino acid metabolism, lipid metabolism, and other branched pathways in TNBC and explore opportunities for new biomarkers, imaging modalities, and metabolically targeted therapies.

【 授权许可】

Unknown