Metabolic tumor burden on postsurgical PET/CT predicts survival of patients with gastric cancer

Cancer Imaging

Gaofeng Sun¹  Tao Wang¹  Jian Yang¹  Xiao Li¹  Chao Cheng¹  Danni Li¹ 

[1] Department of Nuclear Medicine, Changhai Hospital;

关键词: Gastric cancer;    Prognosis;    2-[18F] Fluoro-2-deoxy-D-glucose (18F-FDG);    Positron emission tomography/computed tomography (PET/CT);    Metabolic tumor burden;   

DOI  :  10.1186/s40644-019-0205-9

来源: DOAJ

【 摘 要 】

Abstract Background The prognostic value of postoperative 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) to patients with gastric cancer remains unclear. This study aims to investigate the prognostic value of whole body (WB) metabolic tumor burden (MTBWB) on postsurgical 18F-FDG PET/CT to patients with gastric cancer. Methods A total of 376 patients with surgeries-confirmed gastric cancer were enrolled. Clinicopathologic information, overall survival (OS) and MTBWB parameters on postsurgical PET/CT, in terms of WB maximum standardized uptake value (SUVWBmax), WB metabolic tumor volume (MTVWB), and WB total lesion glycolysis (TLGWB) were collected. In-between differences of patient clinicopathologic characteristics, OS and MTBWB measurements were compared using chi-square test, Fisher’s exact test, Student’s t test or the Kaplan-Meier survival analysis. The optimal cutoffs of MTBWB measurements were calculated through the receiver operating characteristic (ROC) curve analysis. Univariable and multivariable Cox proportional hazard regression were performed to test the predictive value of the clinicopathologic factors and MTBWB measurements to patient survival. Results The PET-positive patients had significantly decreased OS based on either Kaplan-Meier survival analysis (P <  0.001) or univariable Cox regression (hazard ratio [HR] = 2.850, P <  0.001). In patients with PET-positive tumors, the associations between OS and SUVWBmax, MTVWB and TLGWB were significant, both in univariable analysis (P <  0.001, P <  0.001 and P = 0.001, respectively) and in multivariable analysis (P = 0.002, P <  0.001 and P = 0.005, respectively). Patient OS among groups dichotomized by cutoffs of SUVWBmax > 8.6, MTVWB > 91.5 cm3, and TLGWB > 477.6 cm3 were significantly different (P = 0.001, P <  0.001 and P = 0.001, respectively). Conclusions MTBWB, in terms of SUVWBmax, MTVWB and TLGWB, on postsurgical 18F-FDG PET/CT provides prognostic value to patients with gastric cancer after curative resection.

【 授权许可】

Unknown