Archives of Biological Sciences | |
Primary HIV-1 resistance: Persistence of transmitted drug resistance mutations | |
关键词: HIV-1; primary resistance; Q151M complex; viral fitness; persistence; | |
DOI : 10.2298/ABS1204301N | |
来源: DOAJ |
【 摘 要 】
Transmitted drug resistance (TDR) is one of the consequences of the highvariability of HIV-1. The widespread use of antiretroviral therapy for thetreatment of HIV-1 infection results in a large circulating pool of resistantvirus variants. It is known that TDR mutations can persist for extendedperiods and may pose an important problem to the overall success ofantiretroviral therapy. Factors that determine the duration of continuouspersistence of resistance-associated mutations are the number and type ofthese mutations and their impact on viral fitness. Here we describe thefollow-up of a case study of prolonged persistence of resistance-associatedmutations, namely RT mutations Q151M, K65KR and Y181C conferring anintermediate-to-high level resistance to multiple NRTIs and NNRTIs thatlasted for seven years. The infection was caused by subtype G virus.[Projekat Ministarstva nauke Republike SRbije, br. 175024 and The sixthframework European Commission European Commission grant LSHP CT-2006-518211]
【 授权许可】
Unknown