Hepatoma-Derived Growth Factor: An Overview and Its Role as a Potential Therapeutic Target Molecule for Digestive Malignancies

International Journal of Molecular Sciences

Hideji Nakamura¹  Shuhei Nishiguchi²  Hiroki Nishikawa³  Hiroko Iijima³  Hirayuki Enomoto³ 

[1] Department of Gastroenterology and Hepatology, Nippon Life Hospital, Osaka 550-0006, Japan;Department of Internal Medicine, Kano General Hospital, Oska 531-0041, Japan;Division of Gastroenterology and Hepatology, Department of Internal Medicine, Hyogo College of Medicine Nishinomiya, Hyogo 663-8501, Japan;

关键词: hepatoma-derived growth factor (HDGF);    HDGF-related protein;    nucleolin;    cell growth;    angiogenesis;    apoptosis;   

DOI  :  10.3390/ijms21124216

来源: DOAJ

【 摘 要 】

Hepatoma-derived growth factor (HDGF) was identified in research seeking to find a novel growth factor for hepatoma cells. Subsequently, four HDGF-related proteins were identified, and these proteins are considered to be members of a new gene family. HDGF has a growth-stimulating role, an angiogenesis-inducing role, and a probable anti-apoptotic role. HDGF is ubiquitously expressed in non-cancerous tissues, and participates in organ development and in the healing of damaged tissues. In addition, the high expression of HDGF was reported to be closely associated with unfavorable clinical outcomes in several malignant diseases. Thus, HDGF is considered to contribute to the development and progression of malignant disease. We herein provide a brief overview of the factor and its functions in relation to benign and malignant cells. We also describe its possible role as a target molecule for digestive malignancies.

【 授权许可】

Unknown