Synthesis of a new series of 2-hydroxy-5-iodo-N’-(1-arylethylidene)benzohydrazides using a deep eutectic solvent as solvent/catalyst under sonication

Heliyon

The Thai Nguyen¹  Phuong Hoang Tran¹  Cong Tien Nguyen² 

[1] Department of Organic Chemistry, Faculty of Chemistry, University of Science, Vietnam National University, Ho Chi Minh City, 721337, Viet Nam;Faculty of Chemistry, University of Education, Ho Chi Minh City, 700000, Viet Nam;

关键词: Organic chemistry;    Benzohydrazide derivatives;    Deep eutectic solvent;    Green method;    Sonication;   

DOI  :  

来源: DOAJ

【 摘 要 】

We report here the preparation of 2-hydroxy-5-iodo-N’-(1-arylethylidene)benzohydrazide compounds in good to excellent yields (83–98%) within a short reaction time (10–15 min), through a clean and efficient procedure. Seventeen new compounds were synthesized and fully characterized by FT-IR, NMR, and HRMS. The deep eutectic solvent can be recovered easily by phase extraction and can be reused up to several times without any significant loss of catalytic activity. Additionally, the method has a wide substrate scope and provides an accessible route for the large-scale direct synthesis of 2-hydroxy-5-iodo-N’-(1-arylethylidene)benzohydrazides.

【 授权许可】

Unknown